Publications
2026
52. Synthesis of Stereodefined Cyclopropylamine Derivatives from Cyclopropanols and Sulfinamides
Scotchburn, K.; Allen, L. G.; and Rousseaux, S. A. L. Organic Letters. 2026
2025
51. Synthesis of Enantioenriched Borylated Cyclopropanols from Photoexcited Acylsilanes
Palermo, A. F.; Doan, B. A.; and Rousseaux, S. A. L. ACS Catalysis. 2025
50. Overridding Norish Type II to Access Cyclopropanols
Pearson, J. W.; Dudra, S. L.; Palermo, A. F.; Chiu, B. S. Y; Dang, J.; Gabbey, A. L.; Henson, B. A. B.; Hou, T. R.; Nabavi, N.; and Rousseaux, S. A. L. J. Am. Chem. Soc. 2025
49. Ni-Catalyzed Cross-Electrophile Couplings of N-Alkoxyphthalimides and Aryl Halides
Monteith, J. J.; Rousseaux, S. A. L. Eur. J. Org. Chem. 2025, 28.
48. Ni-Catalyzed Reductive Cyanation of Alkenyl Tosylates and Triflates
Graham, J. M.; Rousseaux, S. A. L. Chem. Commun. 2025, 61, 893–896.
2024
47. Alkylarylation of Alkenes for the Synthesis of Spirocyclic gamma-Lactams
Pearson, J. W.; Hou, T. R.; Golijanin, J.; Stewart, P. I.; Choi, E. S.; Gabbey, A. L.; West, M. S.; Rousseaux, S. A. L. Org. Lett. 2024, 26, 5560–5565.
46. A Dual Ni/Photoredox Cross-Coupling Approach toward Mandelic Acids
Monteith, J. J.; Rousseaux, S. A. L. Org. Lett. 2024, 26, 4566–4570.
45. Synthesis of Borylated (Aminomethyl)cyclopropanes Using C1-Bisnucleophiles
McDonald, T. R.; Turner, J. A.; Gabbey, A. L.; Balasubramanian, P.; Rousseaux, S. A. L. Org. Lett. 2024, 26, 3822–3827.
44. Photocatalytic O- to S-Rearrangement of Tertiary Cyclopropanols
Monteith, J. J.; Pearson, J. W.; Rousseaux, S. A. L. Angew. Chem. Int. Ed. 2024, 63, e202402912.
43. Nickel-Catalyzed Synthesis of Benzylamines from (Hetero)aryl Halides and Glycine-Derived N-Hydroxyphthalimide Esters
Choi, E. S.; Rousseaux, S. A. L.; Huestis, M. P. "." Synlett 2024, 35, A–E.
42. Nickel-Catalyzed Reductive Arylation of Redox Active Esters for the Synthesis of α-Aryl Nitriles – Investigation of a Chlorosilane Additive
Michel, N. W. M.; Gabbey, A. L.; Edjoc, R. K.; Fagbola, E.; Hughes, J. M. E.; Campeau, L.-C.; Rousseaux, S. A. L. J. Org. Chem. 2024, 89, 16161–16169.
2023
41. Redox-Active Thiocarbonyl Auxiliaries in Ni-Catalyzed Cross-Couplings of Aliphatic Alcohols
Monteith, J. J.; Rousseaux, S. A. L. Acc. Chem. Res. 2023, 56, 3581–3594.
40. Asymmetric Cu(I)-Catalyzed Conjugate Borylation of α,β-Unsaturated Acyl Silanes
Palermo, A. F.; Imbriaco, B.; Chan, S. C.; Doan, B. A.; Rousseax, S. A. L. Synlett, 2023, 34, A–D. DOI: 10.1055/s-0043-1763621.
39. Nickel-Catalyzed Reductive Alkyne Hydrocyanation Enabled by Malononitrile and a Formaldehyde Additive
Palermo, A. F.; Chiu, B. S. Y.; Patel, P.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2023, 145, 24981–24989.
38. Asymmetric Synthesis of Cyclopropane and Cyclobutane-Containing Small Molecule Pharmaceuticals
Monteith, J. J.; Rousseaux, S. A. L. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering 2022.
37. Metal-Catalysed C–C Bond Formation at Cyclopropanes
Gabbey, A. L.; Scotchburn, K.; Rousseaux, S. A. L. Nat. Rev. Chem. 2023, 7, 548–560.
36. Synthesis of 3-Borylated Cyclobutanols from Epihalohydrins or Epoxy Alcohol Derivatives
McDonald, T. R. M.; Rousseaux, S. A. L. Chem. Sci. 2023, 14, 963–969.
2022
35. Ni-Catalyzed Reductive Cross-Coupling of Cyclopropylamines and Other Strained Ring NHP Esters with (Hetero)Aryl Halides
West, M. S.; Gabbey, A. L.; Huestis, M. P.; Rousseaux, S. A. L. Org. Lett. 2022, 24, 8441–8446.
34. Safe, Selective, and Scaleable Carbenes
West, M. S.; Rousseaux, S. A. L. Science 2022, 377, 580–581.
33. Synthesis of 1- and 1,2-Substituted Cyclopropylamines from Ketone Homoenolates
West, M. S.; Pia, J.; Rousseaux, S. A. L. Org. Lett. 2022, 24, 5869–5873.
32. Synthesis of α-Aryl Secondary Amides via Nickel-Catalyzed Reductive Coupling of Redox-Active Esters
Gabbey, A. L.; Michel, N. W. M.; Hughes, J. M. E.; Campeau, L.-C.; Rousseaux, S. A. L. Org. Lett. 2022, 24, 3173–3178.
31. Decyanation–(hetero)arylation of malononitriles to access α-(hetero)arylnitriles
Mills, L. R.; Patel, P.; Rousseaux, S. A. L. Org. Biomol. Chem. 2022, 20, 5933–5937.
30. Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives
Monteith, J. J.; Scotchburn, K.; Mills, L. R.; Rousseaux, S. A. L. Org. Lett. 2022, 24, 619–624.
2021
29. Ni-Catalyzed C(sp3)–O Arylation of α-Hydroxy Esters
Monteith, J. J.; Rousseaux, S. A. L. Org. Lett. 2021, 23, 9485–9489.
28. Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Teritary Nucleophiles
Mills, L. R.; Edjoc, R. K.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2021, 143, 10422–10428.
27. Selective Carbon–Carbon Bond Cleavage of Cyclopropanols
McDonald, T. R.; Mills, L. R.; West, M. S.; Rousseaux, S. A. L. Chem. Rev. 2021, 121, 3–79.
2020
26. Boronic Acid-Mediated Ring-Opening and Ni-Catalyzed Arylation of 1-Arylcyclopropyl Tosylates
Mills, L. R.; Monteith, J. J.; Rousseaux, S. A. L. Chem. Commun. 2020, 56, 12538–12541.
25. The Cyclopropane Ring as a Reporter of Radical Leaving-Group Reactivity in Ni-Catalyzed C(sp3)–O Arylation
Mills, L. R.; Monteith, J. J.; Gomes, G. P.; Aspuru-Guzik, A.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2020, 142, 13246–13254.
2019
24. Ni-Catalyzed Reductive Cyanation of Aryl Halides and Phenol Derivatives via Transnitrilation
Mills, L. R.; Graham, J.; Patel, P.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2019, 141, 19257–19262.
23. Ni-Catalyzed β-Alkylation of Cyclopropanol-Derived Homoenolates
Mills, L. R.; Zhou, C.; Fung, E.; Rousseaux, S. A. L. Org. Lett. 2019, 21*, 8805–8809.
22. Synthesis of trans-2-Substituted-Cyclopropylamines from α-Chloroaldehydes
West, M. S.; Mills, L. R.; McDonald, T. R.; Lee, J. B.; Ensan, D.; Rousseaux, S. A. L. Org. Lett. 2019, 21, 8409–8413.
21. Nickel-Catalyzed Amination of α-Aryl Methyl Ethers
Patel, P.; Rousseaux, S. A. L. Synlett 2020, 31, 492–396. Part of a special issue dedicated to the 2019 Young Investigators Workshop of the Organic Division of EuCheMS.
20. Synthesis of Nitrile-Bearing Quaternary Centers by an Equilibrium-Driven Transnitrilation and Anion-Relay Strategy
Alazet, S.; West, M. S.; Patel, P.; Rousseaux, S. A. L. Angew. Chem. Int. Ed. 2019, 58, 10300-10304.
19. A one-pot electrophilic cyanation–functionalization strategy for the synthesis of disubstituted malononitriles
Mills, L. R.; Rousseaux, S. A. L. Tetrahedron 2019, 75, 4298-4306. Part of a special issue in honor of Prof. Stephen Buchwald's 2018 Tetrahedron Prize for Creativity in Organic Chemistry.
18. Comparing Industrial Amination Reactions in a Combined Class and Laboratory Green Chemistry Assignment
Obhi, N. K.; Mallov, I.; Borduas-Dedekind, N.; Rousseaux, S. A. L.; Dicks, A. P. J. Chem. Ed. 2019, 96, 93-99.
17. Modern Developments in the Chemistry of Homoenolates
Mills, L. R.; Rousseaux, S. A. L. Eur. J. Org. Chem. 2019, 8-26. Cover Feature.
2018
16. Nickel-Catalyzed Cyanation of Benzylic and Allylic Pivalate Esters
Michel, N. W. M.; Jeanneret, A. D. M.; Kim, H.; Rousseaux, S. A. L. J. Org. Chem. 2018, 83, 11860-11872.
15. Electrophilic Metal Homoenolates and Their Application in the Synthesis of Cyclopropylamines
Mills, L. R.; Rousseaux, S. A. L. "" Synlett 2018, 29, 683-688.
14. Metal-Free Synthesis of Unsymmetrical Ureas and Carbamates from CO2 and Amines via Isocyanate Intermediates
Ren, Y.; Rousseaux, S. A. L. J. Org. Chem. 2018, 83, 913-920.
2017
13. Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines
Mills, L. R.; Barrera Arbelaez, L. M.; Rousseaux, S. A. L. J. Am. Chem. Soc. 2017, 139, 11357-11360.
Before University of Toronto
12. Rousseaux, S. A. L.; Gong, J. Q.; Haver, R.; Odell, B.; Claridge, T. D. W.; Herz, L. M.; Anderson, H. L. "Self-Assembly of Russian Doll Concentric Porphyrin Nanorings" J. Am. Chem. Soc. 2015, 137, 12713-12718.
11. Liu, S.; Kondratuk, D. V.; Rousseaux, S. A. L.; Gil-Ramirez, G.; O'Sullivan, M. C.; Cremers, J.; Claridge, T. D. W.; Anderson, H. L. "Caterpillar Track Complexes in Template-Directed Synthesis and Correlated Molecular Motion" Angew. Chem. Int. Ed. 2015, 54, 5355-5359.
10. Candy, M.; Rousseaux, S. A. L.; San Román, A. C.; Szymczyk, M.; Kafarski, P.; Leclerc, E.; Vrancken, E.; Campagne, J.-M. "Palladium-Catalyzed Hydrophosphonylation of Alkenes with Dialkyl H-Phosphonates" Adv. Synth. Catal. 2014, 356, 2702-2708.
9. Rousseaux, S.; Vrancken, E.; Campagne, J.-M. "Chiral Aryl-Copper(III) Electrophiles: New Opportunities in Catalytic Enantioselective Arylations and Domino Processes" Angew. Chem. Int. Ed. 2012, 51, 10934-10935.
8. Rousseaux, S.; Liégault, B.; Fagnou, K. "C-H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products" in Modern Tools for the Synthesis of Complex Bioactive Molecules (Eds. Cossy, J.; Arseniyadis, S.), Wiley-VCH, 2012, 1-32.
7. Rousseaux, S.; Liégault, B.; Fagnou, K. "Pd(0)-Catalyzed Cyclopropane C-H Bond Functionalization: Synthesis of Quinoline and Tetrahydroquinoline Derivatives" Chem. Sci. 2012, 3, 244-248.
6. Rousseaux, S.; García-Fortanet, J.; Del Aguila Sanchez, M. A.; Buchwald, S. L. "Palladium(0)-Catalyzed Arylative Dearomatization of Phenols" J. Am. Chem. Soc. 2011, 133, 9282-9285.
5. Rousseaux, S.; Davi, M.; Sofack-Kreutzer, J.; Pierre, C.; Jazzar, R.; Kefalidis, C.; Clot, E.; Fagnou, K.; Baudoin, O. "Intramolecular Palladium-Catalyzed Alkane C-H Arylation from Aryl Chlorides" J. Am. Chem. Soc. 2010, 132, 10706-10716.
4. Rousseaux, S.; Gorelsky, S. I.; Chung, B. K. W.; Fagnou, K. "Investigation of the Mechanism of C(sp3)-H Bond Cleavage in Pd(0)-Catalyzed Intramolecular Alkane Arylation Adjacent to Amides and Sulfonamides" J. Am. Chem. Soc. 2010, 132, 10692-10705.
3. Schipper, D. J.; Rousseaux, S.; Fagnou, K. "Kinetic Resolution of Quaternary and Tertiary β-Hydroxy Esters" Angew. Chem. Int. Ed. 2009, 48, 8343-8347.
2. Blaquiere, N.; Shore, D. G.; Rousseaux, S.; Fagnou, K. "Decarboxylative Ketone Aldol Reactions: Development and Mechanistic Evaluation Under Metal-Free Conditions" J. Org. Chem. 2009, 74, 6190-6198.
1. Campeau, L.-C.; Rousseaux, S.; Fagnou, K. "A Solution to the 2-Pyridine Cross-Coupling Problem: Regioselective Catalytic Direct Arylation of Pyridine N-Oxides" J. Am. Chem. Soc. 2005, 127, 18020-18021.